04.07.2019 by

EPO Micro-Dosing May Be Detected by New Test

EPO Micro-Dosing May Be Detected by New Test

The new anti-doping test could detect EPO micro-dosing after 48 hours according to French scientists.

Athletes have never stopped injecting recombinant erythropoietin (rEPO) to enhance their performance in spite of efforts by anti-doping agencies to deter its use. The use of EPO remains widespread in large part because athletes can get away with it.

The athletes have stayed a step ahead of the anti-dopers in the never-ending cat-and-mouse game. The EPO doping strategy of “micro-dosing” has mostly allowed athletes to avoid detection. But the anti-dopers believe they are close to putting an end to this pracctice.

The breakthrough in EPO detection will force athletes to stop using EPO — or adapt.

Michael Audran, the director of the Laboratory of the Agence Française de lutte contre le Dopage (AFDL) in Châtenay-Malabry, announced the breakthrough at a recent AFDL meeting this summer.

The new EPO test has reportedly increased the detection window from a maximum of 24 hours to over 48 hours. For example, a 60-kilogram rider who injected 600 IU would fail a drug tested performed on blood sample collected 48 hours following the micro-dodsing injection.

Athletes have eluded previous attempts, such as the Athlete Biological Passport (ABP), to detect doping by using a combination of blood transfusions and micro-dosing of rEPO. Cyclists, for example, has undergone blood transfusions for a short period of two weeks and have maintained the benefits with micro-doses of EPO every 48 hours.

“It is important [for cheating athletes] to spend 24 to 48 hours [avoiding] detection, because in these protocols, it is estimated that cheaters make microdoses every two days,” Audran explained. “We can detect microdoses EPO a minimum of 48 hours after taking, while it is now difficult to arrive at 24 hours.”

The longer detection-window effectively thwarts the strategy of micro-dosing EPO every 48 hours.

The new EPO test has yet to be fully validated by the World Anti-Doping Agency (WADA). But the Châtenay-Malabry laboratory is confident that it will meet WADA’s approval. The researchers expect the new EPO test to be implement as early as 2020.

  • Arthurs-Brennan, M. (June 14, 2019). Anti-doping laboratory refining test for microdoses of EPO. Retrieved from

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